Delivering Integrated Care Management
The IHTC pharmacy and healthcare professionals interact on a daily basis at our center to maximize coordination and quality of care. Our pharmacists and physicians are on call and available 24 hours a day, seven days a week.
The IHTC pharmacy and healthcare professionals effectively coordinate ongoing care by proactively communicating with our patients to manage clotting factor needs, therapy compliance, and bleeding episodes.
Clotting Disorders
Welcome to the IHTC’s Clotting Disorders webpage. This section provides information on various issues related to clotting disorders that will help you make informed decisions about your care.
How Do I Find the Information I Need?
For an overview of blood clotting disorders (thrombophilia), click here. This section discusses what clotting disorders are, who may be affected, and how the IHTC can help people with clotting disorders.
For information on blood clots in the veins (venous thrombosis), including incidence, causes, special considerations, and services available through the IHTC, click here.
If you need information on a specific condition, click on the appropriate condition in Table 1 (Inherited Causes) or the list below (Acquired Causes).
Inherited Causes of Blood Clots
| Table 1. Inherited Causes of Blood Clots | |||
|---|---|---|---|
| Increased Levels of Procoagulants | Decreased Levels of Anticoagulants | Abnormal Fibrinolysis | Other Inherited Causes |
| Factor V Leiden mutation or activated protein C resistance* | Antithrombin | Plasminogen Deficiency | Paroxysmal Nocturnal Hemoglobinemia |
| Prothrombin 20210 mutation | Protein C | Decreased Levels of Tissue Plasminogen Activator (t-PA) | |
| Hyperhomocysteinemia | Protein S | Increased Levels of Plasminogen Activator Inhibitor-1 (PAI-1) | |
| FVIII, FIX, FXI, FVII, VWF | Thrombomodulin | Elevated Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) | |
| Heparin Cofactor II | |||
| Tissue Factor Pathway Inhibitor (TFPI) | |||
| *The Factor V Leiden mutation does not result in increased FV levels but a resistance to the anticoagulant action of activated protein C. | |||
Acquired Causes of Blood Clots
- Autoimmune disorders: antiphospholipid antibody syndrome, lupus anticoagulant
- Pregnancy
- Hormone therapy
- Cancer
- Myeloproliferative disorders
- Heparin-induced thrombocytopenia
- Immobilization
- Postsurgical state
- Inflammatory disorders
- Nephrotic syndrome
See also our webpage on the IHTC’s anticoagulation clinic and useful information about warfarins’ (Coumadin®) interaction with food. Our Resources webpage provides links to other organizations that serve individuals with clotting disorders and their healthcare providers.
Still have questions? Visit our Clotting Disorder FAQs section or call the IHTC at 317-871-0000 (toll free:877-256-8837 [877-CLOTTER]).