Delivering Integrated Care and Cost Management
The IHTC works collaboratively with payors to optimize care. We ensure that the patients and families we serve have access to care and therapies, thereby helping to contain costs and reduce both bleeding events and utilization of resources.
The IHTC Pharmacy’s ability to purchase clotting factor through the Public Health Service 340B discount program and our overall pricing structure benefit payors and patients by dispensing clotting factor at significantly reduced prices.
Welcome to the IHTC’s Clotting Disorders webpage. This section provides information on a variety of issues related to thrombotic disorders that will help both healthcare providers and patients make informed decisions about their care.
How Do I Find the Information I Need?
For an overview of thrombophilia, click here. This section discusses what thrombophilia is, who may be affected, and how the IHTC can help individuals with thrombophilic conditions.
For information on thrombosis, including incidence, causes, special considerations, and services available through the IHTC, click here.
If you need information on a specific condition, click on the appropriate condition in Table 1 (Inherited Causes) or the list below (Acquired Causes).
Inherited Causes of Thrombosis
|Table 1. Inherited Causes of Venous Thrombosis|
|Increased Levels of Procoagulants||Decreased Levels of Anticoagulants||Abnormal Fibrinolysis||Other Inherited Causes|
|Factor V Leiden mutation or activated protein C resistance*||Antithrombin||Plasminogen Deficiency||Paroxysmal Nocturnal Hemoglobinemia|
|Prothrombin 20210 mutation||Protein C||Decreased Levels of Tissue Plasminogen Activator (t-PA)|
|Hyperhomocysteinemia||Protein S||Increased Levels of Plasminogen Activator Inhibitor-1 (PAI-1)|
|FVIII, FIX, FXI, FVII, VWF||Thrombomodulin||Elevated Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)|
|Heparin Cofactor II|
|Tissue Factor Pathway Inhibitor (TFPI)|
|*The Factor V Leiden mutation does not result in increased FV levels but a resistance to the anticoagulant action of activated protein C.|
Acquired Causes of Thrombosis
- Autoimmune disorders: antiphospholipid antibody syndrome, lupus anticoagulant
- Hormone therapy
- Myeloproliferative disorders
- Heparin-induced thrombocytopenia
- Postsurgical state
- Inflammatory disorders
- Nephrotic syndrome
See also our webpage on the IHTC’s anticoagulation clinic and useful information about vitamin K antagonists’ (Coumadin®) interaction with food. Our Resources webpage provides links to other organizations that serve individuals with clotting disorders and their healthcare providers. Still have questions? Visit our Thrombosis FAQs section or call the IHTC at 317-871-0000 (toll free:877-256-8837 [877-CLOTTER]).