Pharmacy Program

Delivering Integrated Care and Cost Management

The IHTC works collaboratively with payors to optimize care. We ensure that the patients and families we serve have access to care and therapies, thereby helping to contain costs and reduce both bleeding events and utilization of resources.

The IHTC Pharmacy’s ability to purchase clotting factor through the Public Health Service 340B discount program and our overall pricing structure benefit payors and patients by dispensing clotting factor at significantly reduced prices.

Clotting Disorders

Welcome to the IHTC’s Clotting Disorders webpage. This section provides information on a variety of issues related to thrombotic disorders that will help both healthcare providers and patients make informed decisions about their care.

How Do I Find the Information I Need?
For an overview of thrombophilia, click here. This section discusses what thrombophilia is, who may be affected, and how the IHTC can help individuals with thrombophilic conditions.

For information on thrombosis, including incidence, causes, special considerations, and services available through the IHTC, click here.

If you need information on a specific condition, click on the appropriate condition in Table 1 (Inherited Causes) or the list below (Acquired Causes).

Inherited Causes of Thrombosis

Table 1. Inherited Causes of Venous Thrombosis
Increased Levels of Procoagulants Decreased Levels of Anticoagulants Abnormal Fibrinolysis Other Inherited Causes
Factor V Leiden mutation or activated protein C resistance* Antithrombin Plasminogen Deficiency Paroxysmal Nocturnal Hemoglobinemia
Prothrombin 20210 mutation Protein C Decreased Levels of Tissue Plasminogen Activator (t-PA)  
Hyperhomocysteinemia Protein S Increased Levels of Plasminogen Activator Inhibitor-1 (PAI-1)  
FVIII, FIX, FXI, FVII, VWF Thrombomodulin Elevated Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)  
  Heparin Cofactor II    
  Tissue Factor Pathway Inhibitor (TFPI)    
*The Factor V Leiden mutation does not result in increased FV levels but a resistance to the anticoagulant action of activated protein C.

Acquired Causes of Thrombosis

See also our webpage on the IHTC’s anticoagulation clinic and useful information about vitamin K antagonists’ (Coumadin®) interaction with food. Our Resources webpage provides links to other organizations that serve individuals with clotting disorders and their healthcare providers. Still have questions? Visit our Thrombosis FAQs section or call the IHTC at 317-871-0000 (toll free:877-256-8837 [877-CLOTTER]).

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