Blocking Thrombin in Plasma

Heparin cofactor II is found in plasma and rapidly blocks thrombin in the presence of heparin.

Heparin cofactor II deficiency is classified into two ways:

  • Type I (quantitative): a decrease in both cofactor level and its functioning

  • Type II (qualitative): a decrease in the functional activity of the protein with normal cofactor levels

Only a few cases of heparin cofactor II deficiency have been described. Further research is needed to understand the clinical importance of heparin cofactor II deficiency.